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Groupe de recherche du Professeur Richard Leduc - Département de Pharmacologie - Richard.Leduc@USherbrooke.ca
Publications
Sainsily X, Cabana J, Boulais PE, Holleran BJ, Escher E, Lavigne P, Leduc R.
Biochem Pharmacol. 2013 Sep 28. doi:pii: S0006-2952(13)00620-5. 10.1016/j.bcp.2013.09.015. [Epub ahead of print]
PMID: 24084430 [PubMed - as supplied by publisher]
Beaulieu A, Gravel É, Cloutier A, Marois I, Colombo É, Désilets A, Verreault C, Leduc R, Marsault É, Richter MV.
J Virol. 2013 Apr;87(8):4237-51. doi: 10.1128/JVI.03005-12. Epub 2013 Jan 30.
PMID: 23365447 [PubMed - indexed for MEDLINE] Free PMC Article
Boulais PE, Escher E, Leduc R.
Biochem Pharmacol. 2013 Feb 15;85(4):541-50. doi: 10.1016/j.bcp.2012.11.022. Epub 2012 Dec 5.
PMID: 23219524 [PubMed - indexed for MEDLINE]
Critical hydrogen bond formation for activation of the angiotensin II type 1 receptor.
Cabana J, Holleran B, Beaulieu MÈ, Leduc R, Escher E, Guillemette G, Lavigne P.
J Biol Chem. 2013 Jan 25;288(4):2593-604. doi: 10.1074/jbc.M112.395939. Epub 2012 Dec 7.
PMID: 23223579 [PubMed - indexed for MEDLINE]
Matriptase protects against experimental colitis and promotes intestinal barrier recovery.
Netzel-Arnett S, Buzza MS, Shea-Donohue T, Désilets A, Leduc R, Fasano A, Bugge TH, Antalis TM.
Inflamm Bowel Dis. 2012 Jul;18(7):1303-14. doi: 10.1002/ibd.21930. Epub 2011 Nov 13.
PMID: 22081509 [PubMed - indexed for MEDLINE] Free PMC Article
Murza A, Parent A, Besserer-Offroy E, Tremblay H, Karadereye F, Beaudet N, Leduc R, Sarret P, Marsault É.
ChemMedChem. 2012 Feb 6;7(2):318-25. doi: 10.1002/cmdc.201100492. Epub 2011 Dec 13.
PMID: 22170700 [PubMed - indexed for MEDLINE]
Béliveau F, Brulé C, Désilets A, Zimmerman B, Laporte SA, Lavoie CL, Leduc R.
J Biol Chem. 2011 Aug 19;286(33):29035-43. doi: 10.1074/jbc.M111.223461. Epub 2011 Jul 1.
PMID: 21724843 [PubMed - indexed for MEDLINE] Free PMC Article
Influence of Ca2+ and pH on the folding of the prourotensin II precursor.
Bilodeau J, Désilets A, McDuff FO, St-Pierre C, Barbar E, Leduc R, Lavigne P.
FEBS Lett. 2011 Jun 23;585(12):1910-4. doi: 10.1016/j.febslet.2011.04.075. Epub 2011 May 19.
PMID: 21605557 [PubMed - indexed for MEDLINE]
Arsenault J, Cabana J, Fillion D, Leduc R, Guillemette G, Lavigne P, Escher E.
Biochem Pharmacol. 2010 Oct 1;80(7):990-9. doi: 10.1016/j.bcp.2010.06.004. Epub 2010 Jun 19.
PMID: 20599798 [PubMed - indexed for MEDLINE]
Arsenault J, Lehoux J, Lanthier L, Cabana J, Guillemette G, Lavigne P, Leduc R, Escher E.
Pharmacogenet Genomics. 2010 Jun;20(6):377-88. doi: 10.1097/FPC.0b013e32833a6d4a.
PMID: 20436376 [PubMed - indexed for MEDLINE]
Fillion D, Lemieux G, Basambombo LL, Lavigne P, Guillemette G, Leduc R, Escher E.
J Med Chem. 2010 Mar 11;53(5):2063-75. doi: 10.1021/jm9015747.
PMID: 20146480 [PubMed - indexed for MEDLINE]
Yan L, Holleran BJ, Lavigne P, Escher E, Guillemette G, Leduc R.
J Biol Chem. 2010 Jan 22;285(4):2284-93. doi: 10.1074/jbc.M109.077180. Epub 2009 Nov 23.
PMID: 19940150 [PubMed - indexed for MEDLINE] Free PMC Article
Photolabeling identifies transmembrane domain 4 of CXCR4 as a T140 binding site.
Boulais PE, Dulude D, Cabana J, Heveker N, Escher E, Lavigne P, Leduc R.
Biochem Pharmacol. 2009 Dec 1;78(11):1382-90. doi: 10.1016/j.bcp.2009.07.007. Epub 2009 Jul 22.
PMID: 19631193 [PubMed - indexed for MEDLINE]
Domazet I, Martin SS, Holleran BJ, Morin ME, Lacasse P, Lavigne P, Escher E, Leduc R, Guillemette G.
J Biol Chem. 2009 Nov 13;284(46):31953-61. doi: 10.1074/jbc.M109.051839. Epub 2009 Sep 22.
PMID: 19773549 [PubMed - indexed for MEDLINE] Free PMC Article
Activation induces structural changes in the liganded angiotensin II type 1 receptor.
Clément M, Cabana J, Holleran BJ, Leduc R, Guillemette G, Lavigne P, Escher E.
J Biol Chem. 2009 Sep 25;284(39):26603-12. doi: 10.1074/jbc.M109.012922. Epub 2009 Jul 27.
PMID: 19635801 [PubMed - indexed for MEDLINE] Free PMC Article
Characterization of proADAMTS5 processing by proprotein convertases.
Longpré JM, McCulloch DR, Koo BH, Alexander JP, Apte SS, Leduc R.
Int J Biochem Cell Biol. 2009 May;41(5):1116-26. doi: 10.1016/j.biocel.2008.10.008. Epub 2008 Nov 1.
PMID: 18992360 [PubMed - indexed for MEDLINE]
Domazet I, Holleran BJ, Martin SS, Lavigne P, Leduc R, Escher E, Guillemette G.
J Biol Chem. 2009 May 1;284(18):11922-9. doi: 10.1074/jbc.M808113200. Epub 2009 Mar 9.
PMID: 19276075 [PubMed - indexed for MEDLINE] Free PMC Article
Holleran BJ, Domazet I, Beaulieu ME, Yan LP, Guillemette G, Lavigne P, Escher E, Leduc R.
Biochem Pharmacol. 2009 Apr 15;77(8):1374-82. doi: 10.1016/j.bcp.2009.01.013. Epub 2009 Jan 29.
PMID: 19426676 [PubMed - indexed for MEDLINE]
Béliveau F, Désilets A, Leduc R.
FEBS J. 2009 Apr;276(8):2213-26. doi: 10.1111/j.1742-4658.2009.06950.x. Epub 2009 Mar 3.
PMID: 19302215 [PubMed - indexed for MEDLINE]
Clément M, Guillemette G, Leduc R, Escher E.
Adv Exp Med Biol. 2009;611:341-2. No abstract available.
PMID: 19400219 [PubMed - indexed for MEDLINE]
Lysosomotropic drugs inhibit maturation of transforming growth factor-beta.
Basque J, Martel M, Leduc R, Cantin AM.
Can J Physiol Pharmacol. 2008 Sep;86(9):606-12. doi: 10.1139/y08-063.
PMID: 18758509 [PubMed - indexed for MEDLINE]
Proulx CD, Holleran BJ, Boucard AA, Escher E, Guillemette G, Leduc R.
Mol Pharmacol. 2008 Sep;74(3):552-61. doi: 10.1124/mol.108.045054. Epub 2008 May 28.
PMID: 18509066 [PubMed - indexed for MEDLINE] Free Article
Biological properties and functional determinants of the urotensin II receptor.
Proulx CD, Holleran BJ, Lavigne P, Escher E, Guillemette G, Leduc R.
Peptides. 2008 May;29(5):691-9. Epub 2007 Nov 17. Review.
PMID: 18155322 [PubMed - indexed for MEDLINE]
Désilets A, Béliveau F, Vandal G, McDuff FO, Lavigne P, Leduc R.
J Biol Chem. 2008 Apr 18;283(16):10535-42. doi: 10.1074/jbc.M707012200. Epub 2008 Feb 8.
PMID: 18263585 [PubMed - indexed for MEDLINE] Free PMC Article
Martin SS, Holleran BJ, Escher E, Guillemette G, Leduc R.
Mol Pharmacol. 2007 Jul;72(1):182-90. Epub 2007 Apr 19.
PMID: 17446269 [PubMed - indexed for MEDLINE] Free Article
Inhibition of human matriptase by eglin c variants.
Désilets A, Longpré JM, Beaulieu ME, Leduc R.
FEBS Lett. 2006 Apr 17;580(9):2227-32. Epub 2006 Mar 20.
PMID: 16566926 [PubMed - indexed for MEDLINE]
Role of N-glycan-dependent quality control in the cell-surface expression of the AT1 receptor.
Lanctôt PM, Leclerc PC, Escher E, Guillemette G, Leduc R.
Biochem Biophys Res Commun. 2006 Feb 10;340(2):395-402. Epub 2005 Dec 13.
PMID: 16364240 [PubMed - indexed for MEDLINE]
Clément M, Chamberland C, Pérodin J, Leduc R, Guillemette G, Escher E.
J Recept Signal Transduct Res. 2006;26(5-6):417-33.
PMID: 17118790 [PubMed - indexed for MEDLINE]
Methogo RM, Dufresne-Martin G, Leclerc P, Leduc R, Klarskov K.
J Proteome Res. 2005 Nov-Dec;4(6):2216-24.
PMID: 16335969 [PubMed - indexed for MEDLINE]
Lanctot PM, Leclerc PC, Clément M, Auger-Messier M, Escher E, Leduc R, Guillemette G.
Biochem J. 2005 Aug 15;390(Pt 1):367-76.
PMID: 15869468 [PubMed - indexed for MEDLINE] Free PMC Article
Auger-Messier M, Turgeon ES, Leduc R, Escher E, Guillemette G.
Exp Cell Res. 2005 Aug 1;308(1):188-95.
PMID: 15896777 [PubMed - indexed for MEDLINE]
Clément M, Martin SS, Beaulieu ME, Chamberland C, Lavigne P, Leduc R, Guillemette G, Escher E.
J Biol Chem. 2005 Jul 22;280(29):27121-9. Epub 2005 May 12.
PMID: 15890659 [PubMed - indexed for MEDLINE] Free Article
Stability of mutant serpin/furin complexes: dependence on pH and regulation at the deacylation step.
Dufour EK, Désilets A, Longpré JM, Leduc R.
Protein Sci. 2005 Feb;14(2):303-15.
PMID: 15659365 [PubMed - indexed for MEDLINE] Free PMC Article
Involvement of a cytoplasmic-tail serine cluster in urotensin II receptor internalization.
Proulx CD, Simaan M, Escher E, Laporte SA, Guillemette G, Leduc R.
Biochem J. 2005 Jan 1;385(Pt 1):115-23.
PMID: 15458389 [PubMed - indexed for MEDLINE] Free PMC Article
Martin SS, Boucard AA, Clément M, Escher E, Leduc R, Guillemette G.
J Biol Chem. 2004 Dec 3;279(49):51415-23. Epub 2004 Sep 27.
PMID: 15452107 [PubMed - indexed for MEDLINE] Free Article
Auger-Messier M, Arguin G, Chaloux B, Leduc R, Escher E, Guillemette G.
Mol Endocrinol. 2004 Dec;18(12):2967-80. Epub 2004 Aug 26.
PMID: 15331757 [PubMed - indexed for MEDLINE] Free Article
Identification of prodomain determinants involved in ADAMTS-1 biosynthesis.
Longpré JM, Leduc R.
J Biol Chem. 2004 Aug 6;279(32):33237-45. Epub 2004 Jun 7.
PMID: 15184385 [PubMed - indexed for MEDLINE] Free Article
Auger-Messier M, Clement M, Lanctot PM, Leclerc PC, Leduc R, Escher E, Guillemette G.
Endocrinology. 2003 Dec;144(12):5277-84. Epub 2003 Aug 13.
PMID: 12960024 [PubMed - indexed for MEDLINE] Free Article
Boucard AA, Roy M, Beaulieu ME, Lavigne P, Escher E, Guillemette G, Leduc R.
J Biol Chem. 2003 Sep 19;278(38):36628-36. Epub 2003 Jul 3.
PMID: 12842881 [PubMed - indexed for MEDLINE] Free Article
Boucard AA, Sauvé SS, Guillemette G, Escher E, Leduc R.
Biochem J. 2003 Mar 15;370(Pt 3):829-38.
PMID: 12495432 [PubMed - indexed for MEDLINE] Free PMC Article
Residues 293 and 294 are ligand contact points of the human angiotensin type 1 receptor.
Pérodin J, Deraët M, Auger-Messier M, Boucard AA, Rihakova L, Beaulieu ME, Lavigne P, Parent JL, Guillemette G, Leduc R, Escher E.
Biochemistry. 2002 Dec 3;41(48):14348-56.
PMID: 12450401 [PubMed - indexed for MEDLINE]
Polyethylene glycol conjugation at Cys232 prolongs the half-life of alpha1 proteinase inhibitor.
Cantin AM, Woods DE, Cloutier D, Dufour EK, Leduc R.
Am J Respir Cell Mol Biol. 2002 Dec;27(6):659-65.
PMID: 12444025 [PubMed - indexed for MEDLINE]
Leclerc PC, Auger-Messier M, Lanctot PM, Escher E, Leduc R, Guillemette G.
Endocrinology. 2002 Dec;143(12):4702-10.
PMID: 12446598 [PubMed - indexed for MEDLINE] Free Article
Ectodomain shedding of furin: kinetics and role of the cysteine-rich region.
Denault J, Bissonnette L, Longpré J, Charest G, Lavigne P, Leduc R.
FEBS Lett. 2002 Sep 11;527(1-3):309-14.
PMID: 12220680 [PubMed - indexed for MEDLINE]
Processing of proendothelin-1 by members of the subtilisin-like pro-protein convertase family.
Blais V, Fugère M, Denault JB, Klarskov K, Day R, Leduc R.
FEBS Lett. 2002 Jul 31;524(1-3):43-8.
PMID: 12135739 [PubMed - indexed for MEDLINE]
Inhibitory potency and specificity of subtilase-like pro-protein convertase (SPC) prodomains.
Fugère M, Limperis PC, Beaulieu-Audy V, Gagnon F, Lavigne P, Klarskov K, Leduc R, Day R.
J Biol Chem. 2002 Mar 8;277(10):7648-56. Epub 2001 Nov 26.
PMID: 11723118 [PubMed - indexed for MEDLINE] Free Article